Chiral gossypol derivatives: evaluation of their anticancer activity and molecular modeling.

作者: Long Zhang , Haixia Jiang , Xingxin Cao , Huiyun Zhao , Fan Wang

DOI: 10.1016/J.EJMECH.2009.04.025

关键词:

摘要: … of new chiral gossypol analogs for the purpose of finding new anticancer agents. During … (+)-gossypol Schiff bases showed comparable activity with (−)-gossypol. This prompted us to …

参考文章(29)
Andy J. Minn, Rachel E. Swain, Averil Ma, Craig B. Thompson, Recent progress on the regulation of apoptosis by Bcl-2 family members. Advances in Immunology. ,vol. 70, pp. 245- 279 ,(1998) , 10.1016/S0065-2776(08)60388-0
Peter Bushunow, Marcus M. Reidenberg, John Wasenko, Jeffrey Winfield, Beverly Lorenzo, Sheila Lemke, Benjamin Himpler, Robert Corona, Thomas Coyle, Gossypol treatment of recurrent adult malignant gliomas. Journal of Neuro-oncology. ,vol. 43, pp. 79- 86 ,(1999) , 10.1023/A:1006267902186
John C. Reed, BCL-2 FAMILY PROTEINS : STRATEGIES FOR OVERCOMING CHEMORESISTANCE IN CANCER Advances in pharmacology. ,vol. 41, pp. 501- 532 ,(1997) , 10.1016/S1054-3589(08)61070-4
V Dao, Synthesis and cytotoxicity of gossypol related compounds European Journal of Medicinal Chemistry. ,vol. 35, pp. 805- 813 ,(2000) , 10.1016/S0223-5234(00)00165-3
Xianghong Wang, Jin Wang, Stephen C.H. Wong, Lillian S.N. Chow, John M. Nicholls, Y.C. Wong, Yu Liu, Dora L.W. Kwong, Jonathan S.T. Sham, Sai Wah Tsao, Cytotoxic effect of gossypol on colon carcinoma cells Life Sciences. ,vol. 67, pp. 2663- 2671 ,(2000) , 10.1016/S0024-3205(00)00857-2
M.D. Shelley, L. Hartley, R.G. Fish, P. Groundwater, J.J.G. Morgan, D. Mort, M. Mason, A. Evans, Stereo-specific cytotoxic effects of gossypol enantiomers and gossypolone in tumour cell lines. Cancer Letters. ,vol. 135, pp. 171- 180 ,(1999) , 10.1016/S0304-3835(98)00302-4
Roger Adams, T. A. Geissman, J. D. Edwards, Gossypol, a pigment of cottonseed. Chemical Reviews. ,vol. 60, pp. 555- 574 ,(1960) , 10.1021/CR60208A002
Guoping Wang, Zaneta Nikolovska-Coleska, Chao-Yie Yang, Renxiao Wang, Guozhi Tang, Jie Guo, Sanjeev Shangary, Su Qiu, Wei Gao, Dajun Yang, Jennifer Meagher, Jeanne Stuckey, Krzysztof Krajewski, Sheng Jiang, Peter P. Roller, Hatice Ozel Abaan, York Tomita, Shaomeng Wang, Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins. Journal of Medicinal Chemistry. ,vol. 49, pp. 6139- 6142 ,(2006) , 10.1021/JM060460O
Bruce Polsky, Sheldon J. Segal, Penny A. Baron, Jonathan W.M. Gold, Hiroshi Ueno, Donald Armstrong, Inactivation of human immunodeficiency virus in vitro by gossypol Contraception. ,vol. 39, pp. 579- 587 ,(1989) , 10.1016/0010-7824(89)90034-6
E. Montamat, C Burgos, N. Gerez de Burgos, L. Rovai, A Blanco, E. Segura, Inhibitory action of gossypol on enzymes and growth of Trypanosoma cruzi Science. ,vol. 218, pp. 288- 289 ,(1982) , 10.1126/SCIENCE.6750791