Histone Posttranslational Modifications and Chromatin Remodelers in Prostate Cancer

摘要: Prostate cancer (PCa) is one of the most incident and prevalent cancers in men worldwide a leading cause cancer-related morbidity mortality. Epigenetics plays an important role prostate carcinogenesis, namely abnormal expression histone modifier enzymes related chromatin modifications. Notwithstanding, limited knowledge specific deregulated activity/expression modifiers respective modifications hinders their use clinical management, particularly for PCa detection prognostication. Due to limitations analysis global patterns modifications, few studies reported on biomarker potential these epigenetic marks. Importantly, reversible nature makes them promising therapeutic option this malignancy. Indeed, over past years, molecules with inhibitory activity upon machinery have been developed are currently under evaluation trials test effectiveness.