Stability-Indicating Assay, Dissolution, and Content Uniformity of Sodium Levothyroxine in Tablets
作者： Steven L. Richheimer , Tahani M. Amer
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摘要: A reverse-phase high-performance liquid chromatographic (HPLC) method for determining sodium levothyroxine in tablet formulations is described. The was extracted from tablets using a mobile phase consisting of 60% acetonitrile and 40% aqueous buffer. After centrifugation 200 μl the solution chromatographed on 10-μm C18 column. gave accurate results when tested against USP method, by standard additions spiked-placebo method. can also be used to determine content uniformity dissolution tablets.
sci-hub.se 参考文章(12)
M.T.W. Hearn, W.S. Hancock, C.A. Bishop, High-pressured liquid chromatography of amino acids, peptides and proteins Journal of Chromatography A. ,vol. 157, pp. 337- 344 ,(1978) , 10.1016/S0021-9673(00)92351-3
ROBERT A. HATCHER, THE UNITED STATES PHARMACOPEIA. Journal of the American Medical Association. ,vol. L, pp. 30- 34 ,(1908) , 10.1001/JAMA.1908.25310270030002F
Rao S. Rapakax, Patrick W. Knight, Vadlamani K. Prasad, Reversed-Phase High-Performance Liquid Chromatographic Analysis of Liothyronine Sodium and Levothyroxine Sodium in Tablet Formulations: Preliminary Studies on Dissolution and Content Uniformity Journal of Pharmaceutical Sciences. ,vol. 70, pp. 131- 134 ,(1981) , 10.1002/JPS.2600700205
Sheldon S. Stoffer, Potency of Brand Name and Generic Levothyroxine Products JAMA: The Journal of the American Medical Association. ,vol. 244, pp. 1704- 1705 ,(1980) , 10.1001/JAMA.1980.03310150040028
Robert W Rees-Jones, Arturo R Rolla, P Reed Larsen, Hormonal Content of Thyroid Replacement Preparations JAMA: The Journal of the American Medical Association. ,vol. 243, pp. 549- 550 ,(1980) , 10.1001/JAMA.1980.03300320041023
Graham G. Skellern, Massoud Mahmoudian, Barry I. Knight, High-performance liquid chromatographic assays for studying the formation of iodotyrosines and iodothyronines in sheep thyroid peroxidase preparations Journal of Chromatography A. ,vol. 179, pp. 213- 218 ,(1979) , 10.1016/S0021-9673(00)80680-9
Rao S. Rapaka, Patrick W. Knight, Vinod P. Shah, Vadlamani K. Prasad, Analysis of Thyroidal Amino Acids in Pharmaceutical Preparations. I - Reverse Phase High Pressure Liquid Chromatography Analysis of Sodium Liothyronine from Tablets Analytical Letters. ,vol. 12, pp. 1201- 1215 ,(1979) , 10.1080/00032717908067910
Angelita Ramos-Gabatin, In Vivo Comparison of Levothyroxine Preparations JAMA: The Journal of the American Medical Association. ,vol. 247, pp. 203- 205 ,(1982) , 10.1001/JAMA.1982.03320270041021
N M Alexander, M Nishimoto, Rapid analysis for iodotyrosines and iodothyronines in thyroglobulin by reversed-phase liquid chromatography. Clinical Chemistry. ,vol. 25, pp. 1757- 1760 ,(1979) , 10.1093/CLINCHEM/25.10.1757
D. J. Smith, M. Biesemeyer, C. Yaciw, The Separation and Determination of Liothyronine and Levothyroxine in Tablets by Reversed-Phase High Performance Liquid Chromatography Journal of Chromatographic Science. ,vol. 19, pp. 72- 78 ,(1981) , 10.1093/CHROMSCI/19.2.72