Determination of l-thyroxine in reference serum preparations as the o-phthalaldehyde-N-acetylcysteine derivative by reversed-phase liquid chromatography with electrochemical detection
作者： George Lovell , Patrick H. Corran
DOI: 10.1016/S0378-4347(00)83405-2
关键词: Selectivity 、 Quantitative analysis (chemistry) 、 Chromatography 、 Derivative (chemistry) 、 Chemistry 、 Reversed-phase chromatography 、 Fluorescence 、 Acetonitrile 、 O-Phthalaldehyde 、 High-performance liquid chromatography
摘要: Abstract A simple procedure for the assay of l -thyroxine in serum preparations with d as internal standard is described. The extracted acetonitrile, fractionated on a reversed-phase silica cartridge and analysed by high-performance liquid chromatography o-phthalaldehyde-N-acetyl- -cysteine derivative. This derivative not fluorescent, but may be detected suitable sensitivity selectivity an electrochemical detector.
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