Human metapneumovirus and severity of respiratory syncytial virus disease.

摘要: We screened 23 children with severe respiratory syncytial virus (RSV) disease and mild RSV for human metapneumovirus (HMPV). Although HMPV was circulating in Connecticut, none of the 46 RSV-infected patients tested positive HMPV. In our study population, did not contribute to severity disease. In United States, 100,000 infants young are hospitalized each year bronchiolitis (1). risk factors disease, such as prematurity bronchopulmonary dysplasia, well defined, may develop otherwise healthy children. The pathogenesis is poorly defined. In 2001, van den Hoogen et al. reported isolation a novel paramyxovirus, (HMPV) from tract (2). has been identified worldwide (3–7) appears have seasonal distribution (winter spring) (8). Since circulation overlap that RSV, simultaneous infection both disease. Greensill (9) 70% who required admission Pediatric Intensive Care Unit (PICU) Liverpool, U.K. were co-infected HMPV. We sought determine whether associated determined frequency either or Disease assessed by disposition (PICU vs. non-PICU) clinical score.