Lack of intestinal pacemaker (C-KIT-positive) cells in infantile hypertrophic pyloric stenosis☆
作者： Atsuyuki Yamataka , Toshio Fujiwara , Yoshifumi Kato , Tadaharu Okazaki , Masakatsu Suhagawa
DOI: 10.1016/S0022-3468(96)90327-9
关键词:
摘要: The pathogenesis of infantile hypertrophic pyloric stenosis (IHPS) is not well understood. Recent studies have shown that the protonocogene c-kit essential for development or maintenance autonomic gut motility, and also show gene protein product (C-KIT) positive cells in mammalian are responsible intestinal pacemaker activity. This study examines muscles 23 patients (16 with IHPS, 7 controls) presence C-KIT (C-KIT+), using immunohistochemical techniques antihuman sera. In controls, many immunoreactive (IR+) were observed muscle layers. myenteric plexuses demarcated by a moderate number C-KIT-IR+ cells. However, IHPS patients, C-KIT-IR either absent significantly reduced. No found around plexuses. These findings suggest lack expression (as an indicator activity) smooth may be important factor IHPS.
elsevier.com
sci-hub.se 参考文章(20)
F. H. Qiu, P. Ray, K. Brown, P. E. Barker, S. Jhanwar, F. H. Ruddle, P. Besmer, Primary structure of c-kit: relationship with the CSF-1/PDGF receptor kinase family-oncogenic activation of v-kit involves deletion of extracellular domain and C terminus The EMBO Journal. ,vol. 7, pp. 1003- 1011 ,(1988) , 10.1002/J.1460-2075.1988.TB02907.X
Jean-Marie Vanderwinden, Marc-Henri De Laet, Serge N. Schiffmann, Pierre Mailleux, Charles J. Lowenstein, Solomon H. Snyder, Jean-Jacques Vanderhaeghen, Nitric oxide synthase distribution in the enteric nervous system of Hirschsprung's disease Gastroenterology. ,vol. 105, pp. 969- 973 ,(1993) , 10.1016/0016-5085(93)90938-9
D.A. Wattchow, D.T. Cass, J.B. Furness, M. Costa, P.E. O'Brien, K.E. Little, J. Pitkin, Abnormalities of peptide-containing nerve fibers in infantile hypertrophic pyloric stenosis. Gastroenterology. ,vol. 92, pp. 443- 448 ,(1987) , 10.1016/0016-5085(87)90140-5
T. To, B. F. Habbick, C. Khanna, Infantile hypertrophic pyloric stenosis: a study of feeding practices and other possible causes Canadian Medical Association Journal. ,vol. 140, pp. 401- 404 ,(1989)
Y. Yarden, W. J. Kuang, T. Yang-Feng, L. Coussens, S. Munemitsu, T. J. Dull, E. Chen, J. Schlessinger, U. Francke, A. Ullrich, Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand. The EMBO Journal. ,vol. 6, pp. 3341- 3351 ,(1987) , 10.1002/J.1460-2075.1987.TB02655.X
R. Dieler, J. M. Schr�der, Myenteric plexus neuropathy in infantile hypertrophic pyloric stenosis. Acta Neuropathologica. ,vol. 78, pp. 649- 661 ,(1989) , 10.1007/BF00691292
Jan D. Hulzinga, Lars Thuneberg, Michael Klüppel, John Malysz, Hanne B. Mikkelsen, Alan Bernstein, W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity Nature. ,vol. 373, pp. 347- 349 ,(1995) , 10.1038/373347A0
A. Yamataka, Y. Kato, D. Tibboel, Y. Murata, N. Sueyoshi, T. Fujimoto, H. Nishiye, T. Miyano, A lack of intestinal pacemaker (c-kit) in aganglionic bowel of patients with Hirschsprung's disease Journal of Pediatric Surgery. ,vol. 30, pp. 441- 444 ,(1995) , 10.1016/0022-3468(95)90051-9
E. E. Daniel, I. Berezin, H. D. Allescher, H. Manaka, V. Posey-Daniel, Morphology of the canine pyloric sphincter in relation to function. Canadian Journal of Physiology and Pharmacology. ,vol. 67, pp. 1560- 1573 ,(1989) , 10.1139/Y89-251
JohnR. Wesley, MichaelA. DiPietro, ArnoldG. Coran, Pyloric stenosis: evolution from pylorospasm? Pediatric Surgery International. ,vol. 5, pp. 425- 428 ,(1990) , 10.1007/BF00174341