Randomized Clinical Trial: Impact of Oral Administration of Saccharomyces boulardii on Gene Expression of Intestinal Cytokines in Patients Undergoing Colon Resection.
作者： Marcella Lobato D. Consoli , Raphael Steinberg da Silva , Jacques Robert Nicoli , Oscar Bruña-Romero , Rodrigo Gomes da Silva
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摘要: Background:When intestinal microbiota is imbalanced, a patient becomes more vulnerable to infectious complications; intervention with beneficial probiotics may help lower risk for infection. The aim of this study was measure levels inflammatory cytokine messenger RNA (mRNA) in surgical samples mucosal tissues from patients who were given the probiotic Saccharomyces boulardii before undergoing colon surgery. Methods: Thirty-three resection randomly assigned receive at least 7-day preoperative treatment (n = 15) or conventional 18) treatment. Probiotic consisted oral lyophilized S boulardii. Cytokine mRNA (interleukin [IL]–10, IL-1β, IL-23A, tumor necrosis factor [TNF]–α, IL-12B, interferon-γ [INF-γ], and IL-17A) measured obtained during operation. Postoperative infections also assessed. Results: Patients received had significantly IL-10, IL-23A level...
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