A meta-analysis of probiotic and synbiotic use in elective surgery: does nutrition modulation of the gut microbiome improve clinical outcome?

摘要: Background: Perioperative nutrition modulation of gut microbiota is increasingly used as a strategy for reducing the infective complications elective surgery. This meta-analysis assessed effect probiotic and synbiotic preparations on incidence postoperative sepsis. Methods: Randomized controlled trials that compared preoperative dosing probiotics synbiotics in patients undergoing general surgical procedures were included. The primary outcome measure was sepsis rate. Pooled measures determined using random effects models. Results: Thirteen randomized totaling 962 included this analysis (304 received 182 probiotics). reduced group vs control (pooled odds ratio [OR] = 0.42; 95% confidence interval [CI], 0.23–0.75; P .003) OR 0.25; CI, 0.1–0.6; .002). However, subgr...