A Four-Probiotics Regimen Reduces Postoperative Complications After Colorectal Surgery: A Randomized, Double-Blind, Placebo-Controlled Study.

摘要: Heterogeneous results of published studies led to conduct a randomized clinical trial assess the efficacy new formulation four probiotics as prophylaxis for complications after colorectal surgery. A double-blind, placebo-controlled study was conducted enrolling patients undergoing surgery cancer. Capsules placebo or containing Lactobacillus acidophilus, L. p lantarum, Bifidobacterium lactis and Saccharomyces boulardii were administered starting one day before operation continuing another 15 days postoperatively. Patients followed up 30 days with development postoperative primary outcome. Gene expression serum levels cytokines measured on 4 ( www.clinicaltrials.gov NCT02313519). The prematurely stopped enrolment due in Administration significantly decreased rate all major complication (28.6 vs. 48.8 % arm, p 0.010, odds ratio 0.42). Major benefit found reduction pneumonia (2.4 11.3 %, 0.029), surgical site infections (7.1 20.0 %, 0.020) anastomotic leakage (1.2 8.8 %, 0.031). time until hospital discharge shortened well. SOCS3 positively related gene TNF circulating IL-6 probiotic group but not group. studied risk complications, namely mechanical ventilation, leakage. Modulation is suggested mechanism