Antigen Receptors on B Lymphocytes

作者: Michael Reth

DOI: 10.1146/ANNUREV.IY.10.040192.000525

关键词:

摘要: Recent studies on the structure of B cell antigen receptor demonstrate that membrane-bound and antigen-binding immunoglobulin molecules are noncovalently associated with a heterodimer two novel transmembrane proteins. The is thus multicomponent complex whose structural features similar to those T complex. Cross-linking results in rapid tyrosine phosphorylation substrate This suggests belongs subgroup kinase family src-like kinase.

参考文章(118)
J. Wienands, J. Hombach, A. Radbruch, C. Riesterer, M. Reth, Molecular components of the B cell antigen receptor complex of class IgD differ partly from those of IgM. The EMBO Journal. ,vol. 9, pp. 449- 455 ,(1990) , 10.1002/J.1460-2075.1990.TB08130.X
J. Hombach, L. Leclercq, A. Radbruch, K. Rajewsky, M. Reth, A novel 34-kd protein co-isolated with the IgM molecule in surface IgM-expressing cells. The EMBO Journal. ,vol. 7, pp. 3451- 3456 ,(1988) , 10.1002/J.1460-2075.1988.TB03219.X
P M Alzari, M B Lascombe, R J Poljak, Three-Dimensional Structure of Antibodies Annual Review of Immunology. ,vol. 6, pp. 555- 580 ,(1988) , 10.1146/ANNUREV.IY.06.040188.003011
John Rogers, Randolph Wall, Immunoglobulin RNA Rearrangements in B Lymphocyte Differentiation Advances in Immunology. ,vol. 35, pp. 39- 59 ,(1984) , 10.1016/S0065-2776(08)60573-8
Michael R. Gold, Anthony L. Defranco, Biochemistry of B lymphocyte activation. Advances in Immunology. ,vol. 55, pp. 221- 295 ,(1993) , 10.1016/S0065-2776(08)60511-8
T. Taniguchi, T. Kobayashi, J. Kondo, K. Takahashi, H. Nakamura, J. Suzuki, K. Nagai, T. Yamada, S. Nakamura, H. Yamamura, Molecular cloning of a porcine gene syk that encodes a 72-kDa protein-tyrosine kinase showing high susceptibility to proteolysis. Journal of Biological Chemistry. ,vol. 266, pp. 15790- 15796 ,(1991) , 10.1016/S0021-9258(18)98478-4
Lilly Y.W. Bourguignon, Gerard J. Bourguignon, Capping and the Cytoskeleton International Review of Cytology-a Survey of Cell Biology. ,vol. 87, pp. 195- 224 ,(1984) , 10.1016/S0074-7696(08)62443-2