On-line CE-MS using pressurized liquid junction nanoflow electrospray interface and surface-coated capillaries.
作者： Salvatore Fanali , Giovanni D'Orazio , Frantisek Foret , Karel Kleparnik , Zeineb Aturki
关键词:
摘要: A simple and cost-effective laboratory-made liquid junction interface was used for coupling of CE with MS. In this device the capillary column spray tip were positioned in electrode vessel containing appropriate liquid. The electrospray potential applied on inside junction. stable produced at nanoliter per minute flow rates generated emitter without using an external pump. This arrangement provided high durability independent optimization separation (use coated capillaries) ESI conditions. CE-MS analysis mixtures drugs, peptides, tryptic digests proteins biological fluids optimized respect to effects distance between pressure sensitivity system, terms LOD (base peak monitoring) below 10 ng/mL beta-blocker drugs 200 peptide analysis.
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