Patents, ethics, biosafety and regulation using CRISPR technology

Benjamin P. Kleinstiver, Michelle S. Prew, Shengdar Q. Tsai, Ved V. Topkar, Nhu T. Nguyen, Zongli Zheng, Andrew P. W. Gonzales, Zhuyun Li, Randall T. Peterson, Jing-Ruey Joanna Yeh, Martin J. Aryee, J. Keith Joung, Engineered CRISPR-CAS9 nucleases with altered PAM specificity Nature. ,vol. 523, pp. 481- 485 ,(2016) , 10.1038/NATURE14592

Nicolas Wyvekens, Ved V. Topkar, Cyd Khayter, J. Keith Joung, Shengdar Q. Tsai, Dimeric CRISPR RNA-Guided FokI-dCas9 Nucleases Directed by Truncated gRNAs for Highly Specific Genome Editing Human Gene Therapy. ,vol. 26, pp. 425- 431 ,(2015) , 10.1089/HUM.2015.084

Ophir Shalem, Neville E. Sanjana, Ella Hartenian, Xi Shi, David A. Scott, Tarjei S. Mikkelsen, Dirk Heckl, Benjamin L. Ebert, David E. Root, John G. Doench, Feng Zhang, Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells Science. ,vol. 343, pp. 84- 87 ,(2014) , 10.1126/SCIENCE.1247005

Catherine S Manno, Glenn F Pierce, Valder R Arruda, Bertil Glader, Margaret Ragni, John J E Rasko, Margareth C Ozelo, Keith Hoots, Philip Blatt, Barbara Konkle, Michael Dake, Robin Kaye, Mahmood Razavi, Albert Zajko, James Zehnder, Pradip Rustagi, Hiroyuki Nakai, Amy Chew, Debra Leonard, J Fraser Wright, Ruth R Lessard, Jürg M Sommer, Michael Tigges, Denise Sabatino, Alvin Luk, Haiyan Jiang, Federico Mingozzi, Linda Couto, Hildegund C Ertl, Katherine A High, Mark A Kay, Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response Nature Medicine. ,vol. 12, pp. 342- 347 ,(2006) , 10.1038/NM1358

Kevin M Davis, Vikram Pattanayak, David B Thompson, John A Zuris, David R Liu, Small molecule–triggered Cas9 protein with improved genome-editing specificity Nature Chemical Biology. ,vol. 11, pp. 316- 318 ,(2015) , 10.1038/NCHEMBIO.1793

Aparna Surendran, Rogan steps down as USPTO director. Nature Biotechnology. ,vol. 22, pp. 139- 139 ,(2004) , 10.1038/NBT0204-139

Kenneth A. Oye, Kevin Esvelt, Evan Appleton, Flaminia Catteruccia, George Church, Todd Kuiken, Shlomiya Bar-Yam Lightfoot, Julie McNamara, Andrea Smidler, James P. Collins, Regulating gene drives Science. ,vol. 345, pp. 626- 628 ,(2014) , 10.1126/SCIENCE.1254287

András Kupecz, Who owns CRISPR-Cas9 in Europe? Nature Biotechnology. ,vol. 32, pp. 1194- 1196 ,(2014) , 10.1038/NBT.3086

Bernd Zetsche, Sara E Volz, Feng Zhang, A Split Cas9 Architecture for Inducible Genome Editing and Transcription Modulation Nature Biotechnology. ,vol. 33, pp. 139- 142 ,(2015) , 10.1038/NBT.3149

Lakshmi S Vijayachandran, Deepak B Thimiri Govinda Raj, Evelina Edelweiss, Kapil Gupta, Josef Maier, Valentin Gordeliy, Daniel J Fitzgerald, Imre Berger, Gene gymnastics: Synthetic biology for baculovirus expression vector system engineering Bioengineered bugs. ,vol. 4, pp. 279- 287 ,(2013) , 10.4161/BIOE.22966