Carbon dioxide insufflation vs conventional air insufflation for colonoscopy: a systematic review and meta-analysis of published randomized controlled trials

摘要: Aim Conventional air insufflation (AI) may cause prolonged abdominal bloating, excessive pain and discomfort during colonoscopy. Carbon dioxide be an acceptable alternative to avoid these complications. The object of this study was evaluate systematically the effectiveness carbon (CI) for colonoscopy compared with AI. Method Randomized controlled trials (RCTs) comparing CI that AI were retrieved from medical electronic databases combined analysis performed using RevMan statistical package. outcome dichotomous continuous variables expressed as odds ratio (OR) standardized mean difference (SMD). Results Twenty-one RCTs comprising 3607 patients included in study. There statistically significant heterogeneity among studies. showed a trend towards reduced procedural [SMD –1.34; 95% confidence interval (95% CI) −2.23 −0.45; z = 2.96; P < 0.003] also postprocedural at 1 h (SMD –1.11; −1.83 −0.38; z = 2.97; P < 0.003), 6 24 h (OR 0.44; 0.23–0.85; z = 2.44; P < 0.01). associated faster caecal intubation −0.20; −0.37 −0.02; z = 2.23; P < 0.03) but rate similar (P = 0.59) both colonic techniques . Conclusion CI seems have clinical advantages over regard after procedure.