Allelotype analysis of adult T-cell leukemia
作者： Yoshihiro Hatta , Yasuaki Yamada , Masao Tomonaga , Jonathan W. Said , Isao Miyosi
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摘要: Allelotype analysis of adult T-cell leukemia (ATL) was undertaken for the first time to identify chromosomal loci relevant development acute/lymphomatous ATL. Loss heterozygosity (LOH) screened using 94 highly polymorphic microsatellite markers, distributed among all nonacrocentric, autosomal chromosomes. In each 22 cases, DNA obtained from their leukemic cells in phase compared with constitutional mononuclear chronic or remission phase. Allelic losses at least on one chromosome arm occurred 91% cases (20 individuals). Among 39 arms, allelic were observed 31 arms sample. A high frequency loss (>30%) seen 6q (41%) and 17p (48%). The mean fractional (FAL) 0.109. These findings suggest that a novel tumor suppressor gene 6q, as well p53 17p, probably have an important role ATL. © 1998 by American Society Hematology.
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bloodjournal.org参考文章(59)
M Litt, J A Luty, A hypervariable microsatellite revealed by in vitro amplification of a dinucleotide repeat within the cardiac muscle actin gene. American Journal of Human Genetics. ,vol. 44, pp. 397- 401 ,(1989)
G R Hankins, R L Jirtle, M K Washington, T C Orton, A T De Souza, R L Fine, Frequent loss of heterozygosity on 6q at the mannose 6-phosphate/insulin-like growth factor II receptor locus in human hepatocellular tumors. Oncogene. ,vol. 10, pp. 1725- 1729 ,(1995)
Junya Toguchida, Takao Yamamuro, Kanji Ishizaki, Masao S. Sasaki, Yoshihiko Kotoura, Yusuke Nakamura, Norihiko Takada, Noriyoshi Kawaguchi, Yasuhiko Kaneko, Toshikazu Yamaguchi, Allelotype analysis in osteosarcomas: frequent allele loss on 3q, 13q, 17p, and 18q. Cancer Research. ,vol. 52, pp. 2419- 2423 ,(1992)
Andrew Berchuck, John I. Risinger, N. Keith Collins, Jeff Boyd, Jeff Boyd, Hiroyuki Takahashi, J. Carl Barrett, Matthew F. Kohler, Hiroshi Sasaki, Hiroshi Nishii, Fu Shing Liu, Eva Marie Westphal, Takafumi Fujino, Allelotype of Endometrial Carcinoma Cancer Research. ,vol. 54, pp. 4294- 4298 ,(1994)
C. Witkowski, E. Meese, J. Trent, D. Millikin, B. Vogelstein, Loss of Heterozygosity for Loci on the Long Arm of Chromosome 6 in Human Malignant Melanoma Cancer Research. ,vol. 51, pp. 5449- 5453 ,(1991)
Ritva Karhu, Jorma J. Isola, Olli-P. Kallioniemi, Anne H. Kallioniemi, Eija R. Hyytinen, Teuvo Tammela, Tapio Visakorpi, Ann-Christine Syvänen, Genetic Changes in Primary and Recurrent Prostate Cancer by Comparative Genomic Hybridization Cancer Research. ,vol. 55, pp. 342- 347 ,(1995)
Christine E. Belgaid, Jonathan L. Rees, Eugene Healy, Ishtiaq Rehman, Minoru Takata, Howard Rigby, Anders Vahlquist, Allelotypes of Primary Cutaneous Melanoma and Benign Melanocytic Nevi Cancer Research. ,vol. 56, pp. 589- 593 ,(1996)
Albert B Seymour, Ralph H Hruban, Mark Redston, Carlos Caldas, Steve M Powell, Kenneth W Kinzler, Charles J Yeo, Scott E Kern, None, Allelotype of Pancreatic Adenocarcinoma Cancer Research. ,vol. 54, pp. 2761- 2764 ,(1994)
A Sakashita, T Hattori, CW Miller, H Suzushima, N Asou, K Takatsuki, HP Koeffler, Mutations of the p53 gene in adult T-cell leukemia. Blood. ,vol. 79, pp. 477- 480 ,(1992) , 10.1182/BLOOD.V79.2.477.477
J L Weber, P E May, Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction American Journal of Human Genetics. ,vol. 44, pp. 388- 396 ,(1989)