Synthesis and evaluation of the trypanocidal activity of a series of 1,3,4-thiadiazoles derivatives of R -(+)-limonene benzaldehyde-thiosemicarbazones

摘要: In this study, we synthesized a series of 1,3,4-thiadiazole derivatives R-(+)-limonene benzaldehyde-thiosemicarbazones (2a–k). We also determined the cytotoxicity in LLCMK2 cells and activity against epimastigote trypomastigote forms Trypanosoma cruzi, these synthetic compounds without monoterpene (4a–k). 1,3,4-Thiadiazole showed significant trypanocidal high selectivity indexes. The vast majority derivatives, substituted by R-(+)-limonene, presented better anti-T. cruzi than non-substituted compounds. Regarding cytotoxic profile, were, general, less toxic. present findings indicate that 1,3,4-thiadiazoles R-limonene have potential justify further studies to understand mechanism action substances on T. cruzi.