Metformin changes the immune microenvironment of colorectal cancer in patients with type 2 diabetes mellitus.

作者: Akira Saito , Joji Kitayama , Hisanaga Horie , Koji Koinuma , Hideyuki Ohzawa

DOI: 10.1111/CAS.14615

关键词:

摘要: … Metformin has also been shown to mediate the repolarization of macrophages from the M2 to the M1 … As TGF-β is known to be produced by M2-type macrophages, the present study …

参考文章(51)
Úna C. Mc Menamin, Liam J. Murray, Carmel M. Hughes, Chris R. Cardwell, Metformin use and survival after colorectal cancer: A population‐based cohort study International Journal of Cancer. ,vol. 138, pp. 369- 379 ,(2016) , 10.1002/IJC.29720
Andrea DeCensi, Eva Szabo, Sara Gandini, Matteo Puntoni, Brandy M. Heckman-Stoddard, Barbara K. Dunn, Leslie Ford, Metformin and Cancer Risk and Mortality: A Systematic Review and Meta-Analysis taking into account Biases and Confounders Cancer Prevention Research. ,vol. 7, pp. 867- 885 ,(2014) , 10.1158/1940-6207.CAPR-13-0424
Emily J. Gallagher, Derek LeRoith, Diabetes, antihyperglycemic medications and cancer risk: smoke or fire? Current Opinion in Endocrinology, Diabetes and Obesity. ,vol. 20, pp. 485- 494 ,(2013) , 10.1097/01.MED.0000433065.16918.83
Antonio Sica, Paola Larghi, Alessandra Mancino, Luca Rubino, Chiara Porta, Maria Grazia Totaro, Monica Rimoldi, Subhra Kumar Biswas, Paola Allavena, Alberto Mantovani, None, Macrophage polarization in tumour progression. Seminars in Cancer Biology. ,vol. 18, pp. 349- 355 ,(2008) , 10.1016/J.SEMCANCER.2008.03.004
Josie M M Evans, Louise A Donnelly, Alistair M Emslie-Smith, Dario R Alessi, Andrew D Morris, Metformin and reduced risk of cancer in diabetic patients BMJ. ,vol. 330, pp. 1304- 1305 ,(2005) , 10.1136/BMJ.38415.708634.F7
Hiroshi Noto, Atsushi Goto, Tetsuro Tsujimoto, Mitsuhiko Noda, Cancer Risk in Diabetic Patients Treated with Metformin: A Systematic Review and Meta-analysis PLoS ONE. ,vol. 7, pp. e33411- ,(2012) , 10.1371/JOURNAL.PONE.0033411
Zu-Bing Mei, Zhi-Jiang Zhang, Chen-Ying Liu, Yun Liu, Ang Cui, Zhong-Lin Liang, Guang-Hui Wang, Long Cui, Survival Benefits of Metformin for Colorectal Cancer Patients with Diabetes: A Systematic Review and Meta-Analysis PLoS ONE. ,vol. 9, pp. e91818- ,(2014) , 10.1371/JOURNAL.PONE.0091818
Scott A. Hammond, Isabelle Cremer, Diane Damotte, Wolf-Herman Fridman, Catherine Sautès-Fridman, Marie-Caroline Dieu-Nosjean, Jérémy Goc, Claire Germain, Thi Kim Duy Vo-Bourgais, Audrey Lupo, Christophe Klein, Samantha Knockaert, Luc de Chaisemartin, Hanane Ouakrim, Etienne Becht, Marco Alifano, Pierre Validire, Romain Remark, Dendritic cells in tumor-associated tertiary lymphoid structures signal a Th1 cytotoxic immune contexture and license the positive prognostic value of infiltrating CD8+ T cells. Cancer Research. ,vol. 74, pp. 705- 715 ,(2014) , 10.1158/0008-5472.CAN-13-1342
Francesca Bella, Pamela Minicozzi, Adriano Giacomin, Emanuele Crocetti, Massimo Federico, Maurizio Ponz de Leon, Mario Fusco, Rosario Tumino, Lucia Mangone, Orietta Giuliani, Mario Budroni, Milena Sant, Impact of diabetes on overall and cancer-specific mortality in colorectal cancer patients Journal of Cancer Research and Clinical Oncology. ,vol. 139, pp. 1303- 1310 ,(2013) , 10.1007/S00432-013-1439-8
Etan Orgel, Steven D. Mittelman, The Links Between Insulin Resistance, Diabetes, and Cancer Current Diabetes Reports. ,vol. 13, pp. 213- 222 ,(2013) , 10.1007/S11892-012-0356-6