Dendritic cells in tumor-associated tertiary lymphoid structures signal a Th1 cytotoxic immune contexture and license the positive prognostic value of infiltrating CD8+ T cells.

摘要: Tumor-infiltrating T cells, particularly CD45RO(+)CD8(+) memory confer a positive prognostic value in human cancers. However, the mechanisms that promote protective T-cell response tumor microenvironment remain unclear. In chronic inflammatory settings such as microenvironment, lymphoid neogenesis can occur to create local lymph node-like structures known tertiary (TLS). These exacerbate immune response, TLS formation tumors may help an efficacious contexture. role of has yet be investigated carefully. lung tumors, mature dendritic cells (DC) present tumor-associated provide specific marker these structures. this study, we evaluated influence on characteristics infiltrate cohorts prospective and retrospective primary (n = 458). We found high density DC correlated closely strong infiltration are predominantly effector-memory phenotype. Moreover, with expression genes related activation, T-helper 1 (Th1) phenotype, cytotoxic orientation. Lastly, TLS-associated long-term survival, which also allowed distinction patients CD8(+) but risk death. Taken together, our results show how infiltrated by generate contexture characterized Th1 orientation confers lowest Furthermore, findings highlight pivotal function shaping character promoting mediated against cancer.