Tertiary lymphoid organs in infection and autoimmunity.
作者： Katrijn Neyt , Frédéric Perros , Corine H. GeurtsvanKessel , Hamida Hammad , Bart N. Lambrecht
关键词:
摘要: The lymph nodes (LNs) and spleen have an optimal structure that allows the interaction between T cells, B cells antigen-presenting dendritic (DCs) on a matrix made up by stromal cells. Such highly organized can also be formed in tertiary lymphoid organs (TLOs) at sites of infection or chronic immune stimulation. This review focuses molecular mechanisms TLO formation maintenance, controversies surrounding nature inducing events, functions these structures infection, transplantation autoimmunity.
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