Effect of Aging on the Structure and Function of Skeletal Muscle Microvascular Networks

摘要: Humans are active creatures, yet physical activity and tolerance decline over the life span. One prevailing theme in literature to account for a portion of reduced with aging is observation that capacity augment blood flow skeletal muscle may be impaired advancing age. This dysfunction due adaptations structure or function their microvascular networks, which collectively determine resistance. The intent this review present current knowledge networks from special regard how these adapt to, persist through, process. Skeletal muscles supplied by an intricate branching network arterioles venules. consistency findings among available studies suggests overall arteriolar venular topology establishes early development varies little, if at all, Microvascular not series functionally isolated segmental branches. Rather, transmit communicate vasomotor signals along lengths Current evidence associated decrement upstream vessels respond downstream vasodilation transmitted cell-to-cell vascular wall.