Failure of Bcl-2 to block cytochrome c redistribution during TRAIL-induced apoptosis.
作者： Sinead A. Keogh , Henning Walczak , Lisa Bouchier-Hayes , Seamus J. Martin
DOI: 10.1016/S0014-5793(00)01375-2
关键词:
摘要: Tumour necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family cytokines that promotes apoptosis and NF-κB activation. Here we show recombinant hu-TRAIL initiates activation multiple caspases, loss mitochondrial transmembrane potential, cleavage BID redistribution cytochrome c. However, whereas Bcl-2 efficiently blocked UV radiation-induced c release consequent CEM cells, it failed to do either in context TRAIL treatment. Thus, engages death pathway at least partially routed via mitochondria, but contrast with other stimuli engage this pathway, TRAIL-induced not regulated by Bcl-2.
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