Application of central composite design to the optimisation of aqueous two-phase extraction of human antibodies
作者： Paula A.J. Rosa , Ana M. Azevedo , M. Raquel Aires-Barros
DOI: 10.1016/J.CHROMA.2006.11.075
关键词:
摘要: … factorials that have been augmented with a centre point and 2k (k is … of central points [14]. All the 28 (2 4 + 2 × 4 + 4) set point combinations that were performed for the central composite …
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sci-hub.se 参考文章(24)
U. Ney, A. Mountain, D. Schomburg, Gerald Reed, Hans-Jürgen Rehm, Recombinant proteins, monoclonal antibodies and therapeutic genes VCH. ,(1999)
Ralf BOGUMIL, Nham T. NGUYEN, A. Grant MAUK, Gary BRAYER, Robert MAURUS, Structural and spectroscopic studies of azide complexes of horse heart myoglobin and the His-64-->Thr variant. Biochemical Journal. ,vol. 332, pp. 67- 74 ,(1998) , 10.1042/BJ3320067
J.C Marcos, L.P Fonseca, M.T Ramalho, J.M.S Cabral, Application of surface response analysis to the optimization of penicillin acylase purification in aqueous two-phase systems Enzyme and Microbial Technology. ,vol. 31, pp. 1006- 1014 ,(2002) , 10.1016/S0141-0229(02)00230-2
Jon G. Huddleston, Karl W. Ottomar, David M. Ngonyani, Andrew Lyddiatt, Influence of system and molecular parameters upon fractionation of intracellular proteins from Saccharomyces by aqueous two-phase partition. Enzyme and Microbial Technology. ,vol. 13, pp. 24- 32 ,(1991) , 10.1016/0141-0229(91)90184-C
Jonathan Huddleston, Andres Veide, Kristina Köhler, Julia Flanagan, Sven-Olof Enfors, Andrew Lyddiatt, The molecular basis of partitioning in aqueous two-phase systems Trends in Biotechnology. ,vol. 9, pp. 381- 388 ,(1991) , 10.1016/0167-7799(91)90130-A
J.C Marcos, L.P Fonseca, M.T Ramalho, J.M.S Cabral, Partial purification of penicillin acylase from Escherichia coli in poly(ethylene glycol)-sodium citrate aqueous two-phase systems. Journal of Chromatography B: Biomedical Sciences and Applications. ,vol. 734, pp. 15- 22 ,(1999) , 10.1016/S0378-4347(99)00319-9
Roger Sayle, James Milner-White, RASMOL: biomolecular graphics for all Trends in Biochemical Sciences. ,vol. 20, pp. 374- 376 ,(1995) , 10.1016/S0968-0004(00)89080-5
G. KÖHLER, C. MILSTEIN, Continuous cultures of fused cells secreting antibody of predefined specificity Nature. ,vol. 256, pp. 495- 497 ,(1975) , 10.1038/256495A0
P.K. Smith, R.I. Krohn, G.T. Hermanson, A.K. Mallia, F.H. Gartner, M.D. Provenzano, E.K. Fujimoto, N.M. Goeke, B.J. Olson, D.C. Klenk, Measurement of protein using bicinchoninic acid Analytical Biochemistry. ,vol. 150, pp. 76- 85 ,(1985) , 10.1016/0003-2697(85)90442-7
Janice M Reichert, Clark J Rosensweig, Laura B Faden, Matthew C Dewitz, Monoclonal antibody successes in the clinic Nature Biotechnology. ,vol. 23, pp. 1073- 1078 ,(2005) , 10.1038/NBT0905-1073