Effect of Starvation on Central Neurotransmitter Systems and on Endocrine Regulation

摘要: Amenorrhea is one of the early symptoms anorexia nervosa. Detailed analyses 24-h sleep-wake pattern gonadotropin secretion (Pirke et al. 1979) and luteinizing hormone (LH) response to synthetic gonadotropin-releasing (GnRH) (Beumont 1976) have revealed a strict weight dependence in Further support for assumption that decrease may not be primary feature nervosa but consequence starvation loss came from observations dieting healthy female subjects (Vigersky 1977) controlled experiments volunteers (Fichter al., this volume). Although hypothalamic-pituitary-gonadal axis probably influenced by at various levels, main dysfunction occurs hypothalamus. This conclusion can drawn studies Marshall Kelch (1979). In their patients ovulation could induced applying pulsatile LHRH doses over period weeks.