Effects of tris(4-chlorophenyl)methanol on the rat following short-term oral exposure

摘要: The systemic toxicity of tris(4-chlorophenyl)methanol (TCPM) was studied in male and female rats following 4 weeks dietary exposure dosed at 1, 10 100 ppm. An increased spleen to body weight ratio observed males ppm females liver detected both sexes Dose-related increases hepatic Phase-I (AH, APDM, EROD PROD) Phase-II (UDPGT, GST) enzyme activities were generally ppm, with the elevation PROD activity being most marked. Increased urinary ascorbic acid after 1 week treatment At elevated % lymphocytes found males, higher white blood cell lymphocyte counts females. In liver, mild moderate cytoplasmic changes consistent proliferation smooth endoplasmic reticulum present number hepatocytes undergoing apoptosis Mild splenic consisting sinus hyperplasia mantle zone atrophy also observed. It concluded that TCPM a concentration (equivalent 1.2 mg/kg/day) produced included various effects, weight, modulations cells counts.