Natural Interferon α/β–Producing Cells Link Innate and Adaptive Immunity

摘要: Innate immune responses to pathogens critically impact the development of adaptive responses. However, it is not completely understood how innate immunity controls initiation immunities or determines which type will be induced eliminate a given pathogen. Here we show that viral stimulation only triggers natural interferon (IFN)-α/β–producing cells (IPCs) produce vast amounts antiviral IFN-α/β but also induces these differentiate into dendritic (DCs). and tumor necrosis factor α produced by virus-activated IPCs act as autocrine survival DC differentiation factors, respectively. The virus-induced DCs stimulate naive CD4+ T IFN-γ interleukin (IL)-10, in contrast IL-3–induced DCs, helper 2 cytokines IL-4, IL-5, IL-10. Thus, may play two master roles responses: directly inhibiting replication producing large IFN-α/β, subsequently triggering cell–mediated differentiating DCs. constitute critical link between immunity.