Modeling of drosophila circadian system based on locomotor activity

摘要: Due to the 24-hour lighting-dark cycle on earth, circadian rhythm regulates biochemical and physiological processes of almost all living organisms, including plants, insects, mammals. Maintaining regular cyclicity this internal clock, called entrainment, is important well being an organism. For human, disruption can lead lower productivity, digestive problems, decreased sleep efficiency other health problems. Various models have been proposed for rhythm, from empirical oscillator type genetic network based models. These are used gain insight into mechanism governing but may also be formulate light-based control strategies its regulation. As a first step towards our eventual goal light regulation we conducting experiments with drosophila (fruit fly), measuring interaction between intensity wavelength locomotive activity level. Instead high order in past, consider second model, as input output. By entraining flies then observe effect pulses, able identify model parameters input/output experimental data. The shows promising predictive capability: Our simulation that two blue pulses shift phase pacemaker by 12 hours, while experiment result 13.3 hours.