Conserved Hierarchy of Helper T Cell Responses in a Chimpanzee during Primary and Secondary Hepatitis C Virus Infections

摘要: Control of hepatitis C virus (HCV) infection could be influenced by the timing and magnitude CD4+ T cell responses against individual epitopes. We characterized cells targeting seven Pan troglodytes (Patr) class II-restricted epitopes during primary secondary HCV infections a chimpanzee. All Patr-DR-restricted bound multiple human HLA-DR molecules, indicating potential for overlap in targeted both species. Some MHC II molecules efficiently stimulated IL-2 production chimpanzee virus-specific clones. Moreover, one conserved epitope designated NS3(1248) (GYKVLVLNPSV) overlapped helper that is presented humans who spontaneously resolved infection. Resolution was associated with an initial wave limited set dominant including NS3(1248.) A second low-frequency other subdominant appeared blood several weeks later after replication mostly contained. During 7 years later, all sooner at higher frequencies but pattern dominance conserved. In summary, this populations two groups differed frequency kinetics appearance blood. The hierarchial nature response, if broadly applicable to HCV-infected chimpanzees humans, factor governing outcome