Differential regulation of antiviral T-cell immunity results in stable CD8+ but declining CD4+ T-cell memory

摘要: Emerging evidence indicates that CD8+ and CD4+ T-cell immunity is differentially regulated. Here we have delineated differences commonalities among antiviral responses by enumeration functional profiling of eight specific populations during primary, memory recall responses. A high degree coordinate regulation all stood out against an approximately 20-fold lower peak expansion prolonged contraction phase populations. Surprisingly, although was stably maintained for life, levels T cells gradually declined. However, this decay, which seemed to result from less efficient rescue apoptosis, did not affect functionality surviving virus-specific cells. Our results indicate might become limiting under physiological conditions precipitating loss compromise protective even in the presence unimpaired