Adenocarcinosarcoma at the esophagogastric junction with long esophageal invasion: a case report

摘要: Carcinosarcoma of the esophagus or esophagogastric junction (EGJ) is a rare malignancy with both carcinomatous and sarcomatous components. There no report carcinosarcoma arising from EGJ wherein element was adenocarcinoma. We describe patient in which A 52-year-old man diagnosed carcinoma on his after complaining appetite loss. All tumor markers (carcinoembryonic antigen, squamous cell alpha-fetoprotein, carbohydrate antigen 19-9) were within respective normal ranges. Esophagogastroduodenoscopy showed 150-mm (100 mm esophageal side 50 mm gastric side) type 1 EGJ. histopathological examination biopsy specimen revealed well-differentiated tubular adenocarcinoma at side; however, only necrotic tissue noted side. Contrast-enhanced computed tomography did not reveal any invasion adjacent structures; it show five swollen regional lymph nodes. 18F-Fluorodeoxyglucose positron emission distant metastases. performed thoracic subtotal esophagectomy, total gastrectomy, two-field plus left cervical paraesophageal lymphadenectomy. Macroscopically, lesion consisted two components: 7.5-cm 2 9-cm proximal end tumor. Microscopically, predominantly solid cribriform proliferation cells clear cytoplasm, moderately differentiated enteroblastic-like differentiation. The component had periodic acid-Schiff (PAS)-positive globules positive for sal-like protein 4 (SALL 4) negative α-fetoprotein (AFP) human epidermal growth factor receptor (HER2). tumors adenocarcinoma-like spindle (sarcomatous component). Part cartilage lesions continuous lesions. epicenter located present 10 27 resected as