Cytopathic adenoviral E1B mutated viruses for therapy and prophylaxis of neoplasia

摘要: Methods and compositions for treating neoplastic conditions by viral-based therapy are provided. Mutant virus lacking viral proteins which bind and/or inactivate p53 or RB administered to a patient having neoplasm comprises cells function. The mutant is able substantially produce replication phenotype in but unable non-replicating, non-neoplastic essentially normal preferential generation of results killing the cells, either directly expression cytotoxic gene expressing phenotype.