Corpus callosum morphology and relationship to orbitofrontal and lateral ventricular volume in teenagers with first-presentation borderline personality disorder.

摘要: Previous studies have demonstrated alterations to fronto-limbic circuitry and callosal structure in borderline personality disorder (BPD). We predicted that a first-presentation BPD cohort who orbitofrontal cortex (OFC) reductions would show regional the anterior corpus callosum. Method: Twenty teenage patients twenty matched healthy controls underwent Magnetic resonance imaging (MRI) was performed 20 teenaged controls. Corpus callosum size shape ventricular volume were estimated using established methods compared between two groups. The relationship illness variables morphology also examined. OFC correlated with variables. Results: participants did not differ on measures of or shape, size. showed an alteration pattern age-related expansions seen history trauma demonstrate significant neuroanatomical differences from those without. volumes correlate thickness Conclusion: Gross changes are present at level teenagers BPD. Changes other might reflect factors associated duration BPD, such as recurrent comorbidity axis I disorders, treatment.