Persistent Angiogenesis in the Autism Brain: An Immunocytochemical Study of Postmortem Cortex, Brainstem and Cerebellum

摘要: In the current work, we conducted an immunocytochemical search for markers of ongoing neurogenesis (e.g. nestin) in auditory cortex from postmortem sections autism spectrum disorder (ASD) and age-matched control donors. We found nestin labeling cells vascular system, indicating blood vessels plasticity. Evidence angiogenesis was seen throughout superior temporal (primary cortex), fusiform (face recognition center), pons/midbrain cerebellum brains ASD patients but not brains. significant increases both CD34, which are localized to pericyte endothelial cells, respectively. This profile is indicative splitting (intussusceptive), rather than sprouting, constant flux continually expanding.