Septin-Associated Protein Kinases in the Yeast Saccharomyces cerevisiae.

摘要: Septins are a family of eukaryotic GTP-binding proteins that associate into linear rods, which, in turn, polymerize end-on-end filaments and further assemble other, more elaborate super-structures at discrete subcellular locations. Hence, septin-based ensembles considered elements the cytoskeleton. One function these structures has been well-documented studies conducted budding yeast Saccharomyces cerevisiae is to serve as scaffold recruits regulatory proteins, which dictate spatial temporal control certain aspects cell division cycle. In particular, septin-associated protein kinases couple cycle progression with cellular morphogenesis. Thus, septin-containing signaling platforms integrate multitude signals coordinate key downstream networks required for passage. This review summarizes what we currently understand about how action their substrates information flow drive out mitosis, regulate bud growth, especially direct timely efficient execution cytokinesis abscission. septin represent node intersection many pathways. addition, importantly, activities also state organization septins themselves, creating complex feedback loop.