Effect of zearalenone on female White Leghorn chickens.

摘要: Acute toxic effects of purified zearalenone were studied in growing female White Leghorn chickens. In the first experiment, gelatin capsules was administered to 10 chickens (zearalenone-treated [ZC]) a single oral dose 15.0 g/kg. Another control (CC) received empty capsules. All survived 10-day experiment and did not show any noticeable gross or histopathological lesions. There no differences between CC ZC weight gain, oviduct, comb liver weights, hematological parameters, serum cholesterol. had significantly less (P than 0.05) calcium but greater 0.01) phosphorus CC. second orally intramuscularly (pectoral muscle) at levels 0, 50, 200, 400, 800 mg/kg for 7 consecutive days. The oviduct increased with increasing toxin both (OZC) (IZC) groups: there more pronounced IZC. decreased relative estrogenic biopotency IZC, using estradiol dipropionate as standard, 1.37%. results this demonstrate that are highly tolerant when it is multiple doses IZC OZC.