Effect of topical dorzolamide on optic nerve head blood flow

摘要: · Purpose: The topical carbonic anhydrase inhibitor dorzolamide has proven effective in lowering intraocular pressure glaucoma patients. Because an impaired blood supply of the optic nerve to be regarded as a major pathogenic risk factor it seems important examine effect this new antiglaucomatous drug on capillary head flow. Methods: In double-masked, randomized clinical trial, eye drops were applied both eyes 15 healthy subjects (8 female, 7 male, mean age 30.6 years) three times daily for 3 days. control group (15 volunteers, 9 6 30.8 received placebo preparation according same protocol. Intraocular (IOP), pressure, heart rate, flow and retinal measured at baseline (1D0), 90 min after single instillation (1D90), days therapy (3D). Scanning laser Doppler flowmetry (Heidelberg Retina Flowmeter) Riva (Oculix 4000) used measure Results: IOP dropped dorzolamide-treated from 12.5 mmHg 11.0/10.5 (1D0, 1D90, 3DO) 13.0 12.5/12.5 mmHg. Optic by scanning showed no significant changes volunteers (temporal 310/329/315 AU, nasal 387/402/399 AU) or 238/306/276 356/382/379 AU). Also did not show 12.98/12.6/11.7 16.6/16.9/15.7 11.9/12.4/12.4 16.1/15.8/17.7 systemic parameters rate remained unchanged during treatment period. Conclusion: results expected drop IOP. However, flow, two different techniques, change therapy. This may due autoregulation human circulation, which affected dorzolamide.