Chemotherapeutic implications of growth fraction and cell cycle time in glioblastomas.

摘要: ✓Four patients received 3H-thymidine 4 to 7 days and vinblastine 6 hours prior operation for recurrent malignant gliomas (three glioblastomas one anaplastic astrocytoma). Tumor biopsies obtained at were fixed routine histological studies radioautography. The tumors' growth fractions averaged 0.28 with a range of 0.14 0.39. tumor cell cycle time calculated in three had mean duration 57 standard deviation hours. authors concluded that: 1) single short-term courses cell-cycle specific chemotherapeutic agents alone will probably fail achieve either significant reduction mass or dramatic clinical improvement; 2) phase-specific drugs should be administered maintain effective blood levels over 2 3 maximal kill. rate appears correlate the fraction proliferating cells rather than length cycle. scientific basis combination drug multimo...