New generation dopaminergic agents. 7. Heterocyclic bioisosteres that exploit the 3-OH-phenoxyethylamine D2 template
作者： Richard E. Mewshaw , James A. Nelson , Uresh S. Shah , Xiaojie Shi , Hossein Mazandarani
DOI: 10.1016/S0960-894X(99)00434-5
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摘要: Abstract The synthesis of several-bioisosteric analogs based on the 3-OH-phenoxyethylamine dopamine D 2 agonist template (i.e., 3 ) is described. benzimidazol-2-ones and benzthioimidazol-2-ones ( 7–10 2-trifluoromethyl-benzimidazole 13 were observed to have excellent affinity for receptor.
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sci-hub.se 参考文章(8)
Richard E. Mewshaw, Karen L. Marquis, Xiaojie Shi, Georgia McGaughey, Gary Stack, Michael B. Webb, Magid Abou-Gharbia, Theodore Wasik, Rosemary Scerni, Taylor Spangler, Julie A. Brennan, Hossein Mazandarani, Joseph Coupet, Terrance H. Andree, New generation dopaminergic agents 4. Exploiting the 2-methyl chroman scaffold. Synthesis and evaluation of two novel series of 2-(aminomethyl)-3,4,7,9-tetrahydro-2H-pyrano[2,3-e]indole and indol-8-one derivatives Tetrahedron. ,vol. 54, pp. 7081- 7108 ,(1998) , 10.1016/S0040-4020(98)00349-4
Richard E. Mewshaw, Michael B. Webb, Karen L. Marquis, Georgia B. McGaughey, Xiaojie Shi, Theodore Wasik, Rosemary Scerni, Julie A. Brennan, Terrance H. Andree, New Generation Dopaminergic Agents. 6. Structure−Activity Relationship Studies of a Series of 4-(Aminoethoxy)indole and 4-(Aminoethoxy)indolone Derivatives Based on the Newly Discovered 3-Hydroxyphenoxyethylamine D2 Template Journal of Medicinal Chemistry. ,vol. 42, pp. 2007- 2020 ,(1999) , 10.1021/JM990023S
Richard E. Mewshaw, Morris Husbands, Elizabeth S. Gildersleeve, Michael B. Webb, Xiaojie Shi, Hossein Mazandarani, Mark I. Cockett, Rafal Ochalski, Julie A. Brennan, Magid Abou-Gharbia, Karen Marquis, Georgia B. McGaughey, Joseph Coupet, Terrance H. Andree, New generation dopaminergic agents. 2. Discovery of 3-OH-phenoxyethylamine and 3-OH-N1-phenylpiperazine dopaminergic templates Bioorganic & Medicinal Chemistry Letters. ,vol. 8, pp. 295- 300 ,(1998) , 10.1016/S0960-894X(98)00014-6
D. Clark, S. Hjorth, A. Carlsson, Dopamine receptor agonists: mechanisms underlying autoreceptor selectivity. II. Theoretical considerations. Journal of Neural Transmission. ,vol. 62, pp. 171- 207 ,(1985) , 10.1007/BF01252236
Carl Kaiser, Tikam Jain, Dopamine receptors: Functions, subtypes and emerging concepts Medicinal Research Reviews. ,vol. 5, pp. 145- 229 ,(1985) , 10.1002/MED.2610050202
H. Y. Meltzer, S. M. Stahl, The Dopamine Hypothesis of Schizophrenia: A Review* Schizophrenia Bulletin. ,vol. 2, pp. 19- 76 ,(1976) , 10.1093/SCHBUL/2.1.19
Richard E. Mewshaw, Joseph Kavanagh, Gary Stack, Karen L. Marquis, Xiaojie Shi, Michael Z. Kagan, Michael B. Webb, Alan H. Katz, Anna Park, Young H. Kang, Magid Abou-Gharbia, Rosemary Scerni, Theodore Wasik, Luz Cortes-Burgos, Taylor Spangler, Julie A. Brennan, Michael Piesla, Hossein Mazandarani, Mark I. Cockett, Rafal Ochalski, Joseph Coupet, Terrance H. Andree, New generation dopaminergic agents. 1. Discovery of a novel scaffold which embraces the D2 agonist pharmacophore. Structure-activity relationships of a series of 2-(aminomethyl)chromans. Journal of Medicinal Chemistry. ,vol. 40, pp. 4235- 4256 ,(1997) , 10.1021/JM9703653
Oyo Mitsunobu, The Use of Diethyl Azodicarboxylate and Triphenylphosphine in Synthesis and Transformation of Natural Products Synthesis. ,vol. 1981, pp. 1- 28 ,(1981) , 10.1055/S-1981-29317