Perturbations of erythrocyte membrane integrity by subchronic low-level lead exposure in New Zealand white rabbits
作者： Victor M. Ahur , Silvanus M. Anika , Samuel C. Udem
DOI: 10.1007/S00580-018-2679-4
关键词:
摘要: Lead (Pb) poisoning has been recognised as a clinical condition since ancient times. The anaemia frequently observed in Pb is thought to result from the shortening of erythrocytes, life span and inhibition key enzymes haem synthesis [viz. delta aminolevulinic acid dehydratase (ALAD), pyrimidine 5′-nucleotidase type 1 (P5N-1) ferrochelatase]. However, exact mechanism by which shortens erythrocyte still debatable. In present study, effect ingested on membrane sialic content osmotic fragility New Zealand White (NZW) rabbits was studied. Indices exposure, RBC counts, haemoglobin concentration (Hb), haematocrit (PCV), mean corpuscular volume (MCV), (MCH) (MCHC) were investigated. Exposure significantly decreased (p < 0.05) Hb levels, MCV MCH. Similarly, exposure increased Pb-treated animals. It speculated that decreases due subchronic low-level red cell increases fragility.
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