The galanin receptor antagonist M40 blocks the central cardiovascular actions of the galanin N-terminal fragment (1-15).

作者: José A Narváez , Zaida Dı́az-Cabiale , Peter B Hedlund , José A Aguirre , Rafael Coveñas

DOI: 10.1016/S0014-2999(00)00383-6

关键词:

摘要: It has been shown that galanin plays a role in central cardiovascular regulation. Galanin administered centrally induces an increase of heart rate and weak vasodepressor response, whereas the N-terminal fragment (1–15) elicits vasopressor effects tachycardia. Furthermore, it galanin-(1–15), but not galanin-(1–29), decreases baroreceptor reflex sensitivity. Since these data demonstrate both its exert different modulation on control, aim this work to study if specific receptor antagonist Galanin-(1–12)-Pro-(Ala-Leu)2-Ala]-amide (M40) could modulate their actions. Urethane anaesthetized rats were injected intracisternally changes mean arterial pressure monitored. Two doses M40 alone have tested for effects. With dose 1.0 nmol, significant tachycardia was observed (P<0.001), 0.1 nmol ineffective. This suggests possible agonistic effect higher M40. The at failed modify induced by 3.0 galanin-(1–29). However, same completely blocked tachycardic responses elicited galanin-(1–15). These show differentially counteracts give functional support existence subtypes within brainstem. Therefore, present findings can be explained basis actions galanin-(1–29) mediated one type receptor, subtype recognizes fragments may mediate

参考文章(45)
Sophie Papas, Charles W. Bourque, Galanin Inhibits Continuous and Phasic Firing in Rat Hypothalamic Magnocellular Neurosecretory Cells The Journal of Neuroscience. ,vol. 17, pp. 6048- 6056 ,(1997) , 10.1523/JNEUROSCI.17-16-06048.1997
JN Crawley, MC Austin, SM Fiske, B Martin, S Consolo, M Berthold, U Langel, G Fisone, T Bartfai, Activity of centrally administered galanin fragments on stimulation of feeding behavior and on galanin receptor binding in the rat hypothalamus The Journal of Neuroscience. ,vol. 10, pp. 3695- 3700 ,(1990) , 10.1523/JNEUROSCI.10-11-03695.1990
Gregory A. Kinney, Paul J. Emmerson, Richard J. Miller, Galanin Receptor-Mediated Inhibition of Glutamate Release in the Arcuate Nucleus of the Hypothalamus The Journal of Neuroscience. ,vol. 18, pp. 3489- 3500 ,(1998) , 10.1523/JNEUROSCI.18-10-03489.1998
E J Mufson, D C Deecher, O O Odusan, Galanin receptors in human basal forebrain differ from receptors in the hypothalamus: characterization using [125I]galanin (porcine) and [125I]galantide. Journal of Pharmacology and Experimental Therapeutics. ,vol. 275, pp. 720- 727 ,(1995)
I. Merchenthaler, The hypophysiotropic galanin system of the rat brain. Neuroscience. ,vol. 44, pp. 643- 654 ,(1991) , 10.1016/0306-4522(91)90084-2
Kazuhiko Tatemoto, Åke Rökaeus, Hans Jörnvall, Thomas J. McDonald, Viktor Mutt, Galanin — a novel biologically active peptide from porcine intestine FEBS Letters. ,vol. 164, pp. 124- 128 ,(1983) , 10.1016/0014-5793(83)80033-7
R. L. Corwin, J. K. Robinson, J. N. Crawley, Galanin Antagonists Block Galanin‐induced Feeding in the Hypothalamus and Amygdala of the Rat European Journal of Neuroscience. ,vol. 5, pp. 1528- 1533 ,(1993) , 10.1111/J.1460-9568.1993.TB00221.X
T Bartfai, U Langel, K Bedecs, S Andell, T Land, S Gregersen, B Ahrén, P Girotti, S Consolo, R Corwin, Galanin-receptor ligand M40 peptide distinguishes between putative galanin-receptor subtypes Proceedings of the National Academy of Sciences of the United States of America. ,vol. 90, pp. 11287- 11291 ,(1993) , 10.1073/PNAS.90.23.11287
Tor Melander, Tomas Hökfelt, Ake Rökaeus, Distribution of galaninlike immunoreactivity in the rat central nervous system Journal of Comparative Neurology. ,vol. 248, pp. 475- 517 ,(1986) , 10.1002/CNE.902480404