Galanin participates in the functional regulation of the diabetic heart.
作者： Penghua Fang , Jingjing Sun , Xiaoping Wang , Zhenwen Zhang , Ping Bo
DOI: 10.1016/J.LFS.2013.01.024
关键词:
摘要: The diabetic heart is characterized by its impaired ability to utilize glucose. Therapeutic interventions focusing on reducing insulin resistance and enhancing glucose uptake may improve prevention treatment of the heart. Recent studies provided some compelling clues that neuropeptide galanin closely associated with sensitivity in Galanin directly affect homeostasis carbohydrate metabolism cardiac skeletal muscles as well increase transporter 4 (GLUT4) expression translocation insulin-sensitive cells reduce resistance. These findings suggest endogenous has a beneficial effect This paper highlights regulating rate, blood pressure, protect Our findings, therefore, deepen our understanding pathology help evaluate therapeutic potential galanin-receptor ligands for cardiomyopathy.
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