Decreases in the expression of CGRP and galanin mRNA in central and peripheral neurons related to the control of blood pressure following experimental hypertension in rats.
作者： D.R Fior-Chadi , E.F Coelho , M.F.R Ferrari , J.R Maximino , G Chadi
DOI: 10.1016/J.BRAINRESBULL.2004.05.003
关键词:
摘要: Abstract Calcitonin gene-related peptide (αCGRP) and galanin (GAL) are peptides known to participate in central mechanisms of blood pressure control. Nonetheless, variations the synthesis response a hypertensive challenge not well described, specially using model, which allows acute chronic analyses. In this study, we have employed situ hybridization analyse changes mRNA expression αCGRP GAL nucleus tractus solitarii (NTS), hypothalamic paraventricular (PVN) as petrosal nodose ganglia after aortic coarctation-induced hypertension rats. Acute (2 h) (3 7 days) analyses were performed order evaluate involvement both different periods hypertension. The analysis relative levels showed significant differences between sham-operated coarcted was decreased 2 h (40%) 3 days (42%) ganglia, respectively, coarctation. No CGRP signal seen NTS PVN analysed periods. (19%) (55%), days, observed following Data suggest that may involved establishment/maintenance induced by might be with adaptation state, while at phase related counteraction
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