Model-Free Linkage Analysis of a Binary Trait

摘要: Genetic linkage analysis aims to detect chromosomal regions containing genetic variants that influence risk of specific inherited diseases. The presence is indicated when a disease or trait cosegregates through the families with markers at particular region genome. Two main types are in common use, namely model-based and model-free analysis. In this chapter, we focus solely on latter type specifically binary traits phenotypes, such as absence disease. Model-free based allele-sharing, where patterns similarity among affected relatives compared chance expectations. Because methods do not require specification inheritance parameters model, they preferred by many researchers early stages study complex We introduce history Subheading 1. Table 1 describes standard workflow. describe three popular methods, nonparametric (NPL) statistic, sib-pair (ASP) likelihood ratio test, approach for pedigrees. theory behind each test described section together simple example relevant calculations. 4 provides summary software packages implement models. 2, work rich providing sample code output. 3 contains notes additional details various topics may need further consideration during