作者: C. P. W. G. M. Verwey-Van Wissen , E. W. J. Van Ewijk-Beneken Kolmer , T. B. Vree , Y. A. Hekster
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摘要: We studied the effects of urinary pH on kinetics salicylic acid (SA) with its metabolites and assessed contribution alkaline hydrolysis acyl glucuronide to renal clearance acid. Hydrolysis SAAG in urine contributes marginally high excretion acid, validating alkalinization a patient SA overdose. Under acidic conditions, had terminal plasma t1/2 value 3.29 +/- 0.52 hours while under conditions this was significantly reduced 2.50 0.41 (p = 0.0156). The total oral body (1.38 0.43 l/h) is lower than (2.27 0.83 l/h; p 0.0410). Km Vmax values SA, conjugates phenolic (SAPG), salicyluric (SU) (SUPG) did not differ statistically conditions. protein binding 93.8 1.0% that SU 89.7 2.2% vivo vitro. SUPG 84.8 1.8%, SAPG showed no at all. depends strongly pH. percentage dose excreted unchanged increased from 2.3 1.5% 30.5 9.1% 0.0006). Alkaline lowered by 50% as 0.0028), 0.0013), 0.0296), only 0.0589).(ABSTRACT TRUNCATED AT 250 WORDS)