Saturable Active Tubular Reabsorption in the Renal Clearance of Mesalazine in Human Volunteers
作者： Tom B. Vree , Erik Dammers , Peter S. Exler , Fritz S??rgel , Robert A.A. Maes
DOI: 10.2165/00044011-200020010-00005
关键词:
摘要: Objective: To identify the reasons for large variation in renal clearance of mesalazine.
springer.com
ru.nl
core.ac.uk 
sci-hub.se 参考文章(25)
Allgayer H, Sonnenbichler J, Paumgartner G, Kruis W, Determination of the pK values of 5-aminosalicylic acid and N-acetylaminosalicylic acid and comparison of the pH dependent lipid-water partition coefficients of sulphasalazine and its metabolites. Drug Research. ,vol. 35, pp. 1457- 1459 ,(1985)
Amitabh Prakash, Anthony Markham, Oral delayed-release mesalazine: A review of its use in ulcerative colitis and Crohn's disease Drugs. ,vol. 57, pp. 383- 408 ,(1999) , 10.2165/00003495-199957030-00013
E. Noble, L. Janssen, P.J. Dierickx, Comparative cytotoxicity of 5-aminosalicylic acid (mesalazine) and related compounds in different cell lines. Cell Biology and Toxicology. ,vol. 13, pp. 445- 451 ,(1997) , 10.1023/A:1007423911613
C. P. W. G. M. Verwey-Van Wissen, E. W. J. Van Ewijk-Beneken Kolmer, T. B. Vree, Y. A. Hekster, Effect of urinary pH on the pharmacokinetics of salicylic acid, with its glycine and glucuronide conjugates in human. International Journal of Clinical Pharmacology and Therapeutics. ,vol. 32, pp. 550- 558 ,(1994)
James E. F. Reynolds, William Martindale, The Extra Pharmacopoeia ,(2018)
Ian Ahnfelt-Rønne, Ole Haagen Nielsen, Annelise Christensen, Ebbe Langholz, Vibeke Binder, Povl Riis, Clinical Evidence Supporting the Radical Scavenger Mechanism of 5-Aminosalicylic Acid Gastroenterology. ,vol. 98, pp. 1162- 1169 ,(1990) , 10.1016/0016-5085(90)90329-Y
STIG BONDESEN, STEN NØRBY RASMUSSEN, JØRGEN RASK-MADSEN, OLE HAAGEN NIELSEN, KARSTEN LAURITSEN, VIBEKE BINDER, STEEN HONORÉ HANSEN, EIGILL F. HVIDBERG, 5-Aminosalicylic Acid in the Treatment of Inflammatory Bowel Disease Acta Medica Scandinavica. ,vol. 221, pp. 227- 242 ,(2009) , 10.1111/J.0954-6820.1987.TB00889.X
TOM B. VREE, ERIK DAMMERS, PETER S. EXLER, ROBERT A. A. MAES, Mono- and biphasic plasma concentration-time curves of mesalazine from a 500 mg suppository in healthy male volunteers controlled by the time of defecation before dosing. Journal of Pharmacy and Pharmacology. ,vol. 52, pp. 645- 652 ,(2010) , 10.1211/0022357001774471
SANDRA P. A. BOOM, ALFONS C. WOUTERSE, TOM B. VREE, CEES A. M. GINNEKEN, FRANS G. M. RUSSEL, Renal tubular excretion of the N4-acetyl metabolites of sulphasomidine and sulphadimethoxine in the dog. Journal of Pharmacy and Pharmacology. ,vol. 45, pp. 614- 617 ,(2011) , 10.1111/J.2042-7158.1993.TB05663.X
B. A. Jacobsen, K. Abildgaard, H. H. Rasmussen, L. A. Christensen, J. Fallingborg, S. H. Hansen, S. Nørby Rasmussen, Availability of mesalazine (5-aminosalicylic acid) from enemas and suppositories during steady-state conditions. Scandinavian Journal of Gastroenterology. ,vol. 26, pp. 374- 378 ,(1991) , 10.3109/00365529108996497