Ageing, Cellular Senescence and Neurodegenerative Disease.
作者： Marios Kritsilis , Sophia V. Rizou , Paraskevi Koutsoudaki , Konstantinos Evangelou , Vassilis Gorgoulis
DOI: 10.3390/IJMS19102937
关键词:
摘要: Ageing is a major risk factor for developing many neurodegenerative diseases. Cellular senescence homeostatic biological process that has key role in driving ageing. There evidence senescent cells accumulate the nervous system with ageing and disease may predispose person to appearance of condition or aggravate its course. Research into long been hindered by variable cell-type specific features lack universal marker unequivocally detect cells. Recent advances markers genetically modified animal models have boosted our knowledge on cellular age-related disease. The aim now fully elucidate neurodegeneration order efficiently safely exploit as therapeutic target. Here, we review neurons glial discuss putative Alzheimer’s disease, Parkinson’s multiple sclerosis provide, first time, glia sclerosis, using novel GL13 lipofuscin stain senescence.
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