Water-soluble vitamin homeostasis in fasting northern elephant seals (Mirounga angustirostris) measured by metabolomics analysis and standard methods.

摘要: Despite the importance of water-soluble vitamins to metabolism, there is limited knowledge their serum availability in fasting wildlife. We evaluated changes northern elephant seals, a species with an exceptional ability withstand nutrient deprivation. used metabolomics approach measure and associated metabolites under extended natural fasts for up 7 weeks free-ranging lactating or developing seals. Water-soluble were not detected this platform, but could be measured standard assays. Concentrations varied independently, all maintained at detectable levels over fasts, suggesting that defense vitamin component adaptation Metabolomics was ideal generating complete profiles species, gave novel insights into metabolism by detecting key related metabolites. For example, niacin level reductions females significant precursors downregulation synthetic pathway. The detect individual using may impacted large number compounds detected. Modifications analysis platforms compound detection algorithms study required improving other wildlife systems.