Multifunctional Gd,Ce,Tb co-doped β-tricalcium phosphate porous nanospheres for sustained drug release and bioimaging.

摘要: Multifunctional Gd,Ce,Tb co-doped β-tricalcium phosphate (TCP) porous nanospheres are prepared by a facile solvothermal strategy with trimethyl as the phosphorus source. The as-prepared nanomaterial (average diameter of 100 nm) has multiple level pore size distribution specific surface area 124.33 m2 g−1, which benefits drug loading. Its photoluminescent and magnetic multifunctions realized co-doping Gd3+, Ce3+ Tb3+ ions, make promising for both fluorescence resonance imaging techniques. Furthermore, exhibits excellent cytocompatibility relatively high doxorubicin loading capacity well sustained pH-sensitive release behaviour. It is suggested that β-TCP applications in biomedical fields such multifunctional delivery systems tissue engineering scaffolds bioimaging guidance.