Transcriptional activation of collagenase‐3 by transforming growth factor‐β1 is via MAPK and Smad pathways in human breast cancer cells
作者： Nagarajan Selvamurugan , Ziawei Fung , Nicola C Partridge
DOI: 10.1016/S0014-5793(02)03620-7
关键词:
摘要: Transforming growth factor (TGF)-beta1, a crucial molecule in metastatic bone cancer, stimulates collagenase-3 expression the human breast cancer cell line, MDA-MB231. Cycloheximide inhibited this stimulation, indicating that de novo protein synthesis was essential for response. We examined whether mitogen-activated kinase (MAPK) and/or Smad pathways are involved TGF-beta1-stimulated MDA-MB231 cells. Biochemical blockade of extracellular regulated kinase-1/2 and p38 MAPK partially abolished mRNA expression; whereas overexpression dominant negative form Smad3 completely blocked TGF-beta1-response. These data indicate TGF-beta1-induced
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