Steroidogenic factor 1 directs programs regulating diet-induced thermogenesis and leptin action in the ventral medial hypothalamic nucleus

摘要: The transcription factor steroidogenic 1 (SF-1) is exclusively expressed in the brain ventral medial hypothalamic nucleus (VMH) and required for development of this nucleus. However, physiological importance transcriptional programs regulated by SF-1 VMH not well defined. To delineate functional significance itself brain, we generated pre- postnatal VMH-specific KO mice. Both models were susceptible to high fat diet-induced obesity displayed impaired thermogenesis after acute exposure diet. Furthermore, mice showed significantly decreased LepR expression specifically VMH, leading leptin resistance. Collectively, these results indicate that directs hypothalamus relevant coordinated control energy homeostasis, especially excess caloric intake.