Vitamin D Supplementation and Fracture Incidence in Elderly Persons
作者： Paul Lips
DOI: 10.7326/0003-4819-124-4-199602150-00003
关键词:
摘要: OBJECTIVE: To determine whether vitamin D supplementation decreases the incidence of hip fractures and other peripheral bone fractures. DESIGN: Prospective, double-blind trial. SETTING: Community setting (Amsterdam surrounding area). PATIENTS: 2578 persons (1916 women, 662 men) 70 years age older (mean +/- SD, 80 6 years) living independently, in apartments for elderly persons, or homes persons. INTERVENTION: Participants were randomly assigned to receive either D3, 400 IU one tablet daily, placebo a maximum 3.5 years. MEASUREMENTS: Dietary calcium intake serum 25-hydroxyvitamin [25(OH)D] estimated subset participants. During follow-up, attention was concentrated on The maximal follow-up period 4 results evaluated by survival analysis. RESULTS: Mean dietary from dairy products 868 mg/d. 25(OH)D concentration third year study 23 nmol/L group 60 group. Median years, total 8450 patient-years. 306 282 died (P = 0.20). Hip occurred 48 58 0.39, intention-to-treat analysis). Other 74 77 0.86). CONCLUSION: Our do not show decrease Dutch after supplementation. Language: en
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