Cytotoxic action of Brazilian propolis in vitro on canine osteosarcoma cells
作者： N. C. Cinegaglia , P. R. O. Bersano , M. C. Búfalo , J. M. Sforcin
DOI: 10.1002/PTR.4861
关键词:
摘要: Osteosarcoma (OSA) is a primary bone neoplasm frequently diagnosed in dogs. The biology of OSA pet dogs identical to that pediatric patients, and it has been considered an excellent model vivo study human OSA. Since the individual response chemotherapy unpredictable considering propolis natural product with several biological properties, this work evaluated cytotoxic action on canine cells. cell culture was obtained from tumor dog Cell viability assessed after incubation propolis, 70% ethanol (propolis solvent), carboplatin 6, 24, 48, 72 h. analyzed by crystal violet method. Data showed cells were sensitive dose- time-dependent manner had distinct morphology compared control. Its solvent (70% ethanol) no effect viability, suggesting exclusively due propolis. Our sample exerted cells, its introduction as possible therapeutic agent could be investigated, providing new contribution treatment.
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G. Boudourova-Krasteva, Vassya Bankova, J. M. Sforcin, N. Nikolova, S. Popov, Phenolics from Brazilian Propolis Zeitschrift für Naturforschung. C. A journal of biosciences. ,vol. 52, pp. 676- 679 ,(1997) , 10.1515/ZNC-1997-9-1016
K. G. Thompson, R. R. Pool, Tumors of Bones Tumors in Domestic Animals. pp. 245- 317 ,(2008) , 10.1002/9780470376928.CH5
T. F. Bachiega, C. L. Orsatti, A. C. Pagliarone, J. M. Sforcin, The Effects of Propolis and its Isolated Compounds on Cytokine Production by Murine Macrophages Phytotherapy Research. ,vol. 26, pp. 1308- 1313 ,(2012) , 10.1002/PTR.3731
Ricardo G Woisky, Antonio Salatino, Analysis of propolis: some parameters and procedures for chemical quality control Journal of Apicultural Research. ,vol. 37, pp. 99- 105 ,(1998) , 10.1080/00218839.1998.11100961
Ahmet Guney, Ibrahim Karaman, Mithat Oner, Mukerrem Betul Yerer, Effects of propolis on fracture healing: an experimental study. Phytotherapy Research. ,vol. 25, pp. 1648- 1652 ,(2011) , 10.1002/PTR.3470
J.M. Sforcin, R.O. Orsi, V. Bankova, Effect of propolis, some isolated compounds and its source plant on antibody production Journal of Ethnopharmacology. ,vol. 98, pp. 301- 305 ,(2005) , 10.1016/J.JEP.2005.01.042
Vassya Bankova, Gergana Boudourova-Krasteva, Jose M. Sforcin, Xavier Frete, Atanas Kujumgiev, Rita Maimoni-Rodella, Simeon Popov, Phytochemical Evidence for the Plant Origin of Brazilian Propolis from São Paulo State Zeitschrift für Naturforschung C. ,vol. 54, pp. 401- 405 ,(1999) , 10.1515/ZNC-1999-5-616
Muneo Motomura, Kyung Min Kwon, Seok-Jong Suh, Young-Choon Lee, Yeon-Kye Kim, In-Seon Lee, Myung-Sunny Kim, Dae Young Kwon, Ikukatsu Suzuki, Cheorl-Ho Kim, None, Propolis induces cell cycle arrest and apoptosis in human leukemic U937 cells through Bcl-2/Bax regulation Environmental Toxicology and Pharmacology. ,vol. 26, pp. 61- 67 ,(2008) , 10.1016/J.ETAP.2008.01.008
Birgitt Wolfesberger, Ingrid Walter, Claudia Hoelzl, Johann G. Thalhammer, Monika Egerbacher, Antineoplastic effect of the cyclooxygenase inhibitor meloxicam on canine osteosarcoma cells. Research in Veterinary Science. ,vol. 80, pp. 308- 316 ,(2006) , 10.1016/J.RVSC.2005.07.013
H. Robson, S. Meyer, S.M. Shalet, E. Anderson, S. Roberts, O.B. Eden, Platinum agents in the treatment of osteosarcoma: efficacy of cisplatin vs. carboplatin in human osteosarcoma cell lines. Medical and Pediatric Oncology. ,vol. 39, pp. 573- 580 ,(2002) , 10.1002/MPO.10076